A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth
نویسندگان
چکیده
منابع مشابه
A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.
Hippo signaling is a critical player in controlling the growth of several tissues and organs in diverse species. The current model of Hippo signaling postulates a cascade of kinase activity initiated by the MST1/2 kinases in response to external stimuli. This leads to inactivation of the transcriptional coactivators, YAP/TAZ, due to their cytoplasmic retention and degradation that is correlated...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2015
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2015.04.014